MARROW ADIPOSITY & BONE Lab

ULR 4490

Stephanie Lucas

Stephanie Lucas

Research professor

Contact, L

Contact:

Stephanie.Lucas@univ-littoral.fr

Research Unit(s):

MABLab ULR 4490 – University of the Littoral Côte d’Opale

Team-project:

Functional regulation of Bone Marrow Adipocytes as a link between metabolic diseases and osteoporosis

Research discipline:

Natural science: Cellular and Molecular Biology, Mouse models, Clinical bone and bone marrow samples, Adipocyte isolation, Functional tests related to energy, metabolism, Extracellular Matrix isolation, Bone formation tests

Medical and Health Sciences: Bone Marrow Adiposity, Adipose tissues, Osteoporosis, Menopause, Obesity, Type 2 diabetes

Expertise:

  • Phenotype and regulation of several adipocyte types
  • Loss of bone formation and bone quality
  • Involvement of metabolites (glucose, free fatty acids) and ROS in bone defects
  • Menopause, obesity and type 2 diabetes related-osteoporosis

Projects:

As principal investigator

  • Research grant from MSD Avenir Foundation (2018-2023): ADIMetabone project around the « Functional regulation of bone marrow adipocytes: towards a link between metabolic diseases and bone defects». This transversal project aimed at deciphering 1) the importance of chronic exposure to high glucose concentration of Bone Marrow Mesenchymal Stromal cells-derived adipocytes with regard with their ROS and adipokine production, their extracellular matrix synthesis and impact on osteogenesis; 2) the relevance of lowering glycaemia in the prediabetic model of ovariectomized mice regarding Bone Marrow Adiposity, bone content and quality; and 3) how the phenotype of femoral Bone Marrow Adipocytes is associated with metabolic parameters in post-menopausal patients with knee prosthetic surgery, in comparison with subcutaneous adipocytes (Clinical protocol MEDADIPO, gov ID: NCT03678831), in collaboration with Dr T. RHARASS (postdoctoral fellow), Dr L. ENTZ (doctoral project), Lille Hospital [CRB, Dr S. PUTMAN and Dr J. DARTUS (Orthopaedic surgeons)], and MABLab members [Dr G. FALGAYRAC (Raman analyses), Dr D. LETERME (experimental surgery), V. GAUTHIER (animal experiments), S. DELPLACE (Histology), F. MIELLOT (X-ray micro-computed tomography), Pr G. PASQUIER (Orthopaedic surgeon), Pr B. CORTET (Rheumatologist)].
  • BQR from ULCO (2017): NAPROT Imaging for the acquisition of an Imager 600RGB (Amersham) to analyse proteins and nucleic acids following fluorescent labelling, ECL and colorimetry.
  • Research grants from the French Society of Mineralized Tissue Biology (SFBTM) and ULCO (2013) for the training of S. DELPLACE to bone and bone marrow Immuno-Histo-Chemistry (IHC).
  • Research grant from the French Society of Rheumatology SFR (2012): « Secretions of bone marrow adipocytes in alterations of bone remodelling of the ovariectomy model», which aimed at characterizing the phenotype of Bone Marrow Adipocytes isolated from long bones of ovariectomized mice in comparison with isolated visceral and subcutaneous adipocytes, with MABLab members [Dr D. LETERME (experimental surgery), S. DELPLACE (Histology), A. RESONNET and F. MIELLOT (animal experiments).]

 

As co-investigator

  • Research grant from the French Society of Rheumatology SFR (2016-2020) in collaboration with Pr X. HOUARD (PI, INSERM UMR_S938. Hôpital Saint-Antoine, Paris) and Pr M.H. LAFAGE-PROUST (INSERM 1059, Faculté de médecine, St Etienne): « Involvement of Bone Marrow Adipose Tissue in bone homeostasis during age-associated diseases », which aimed at assessing the involvement of Bone Marrow Adipocytes in the development of osteoarthritis in comparison of osteoporosis through various mouse and cell models and clinical samples.
  • BQR from ULCO (2011) in collaboration with Pr Christophe CHAUVEAU for the acquisition of a DEXA equipment (Lunar Piximus) for the determination of fat, lean and mineral masses of mice.

 

Activities

  • Teaching (CNU section 65) in Bachelor of Life Sciences (ULCO, since 2010), in Master of Biology & Health (Paris Cité-Sorbonne 2023; Lille 2015-2020)
  • Member of the French Society for the Biology of Mineralized Tissues (SFBTM) Scientific Board since 2025
  • Editorial Board Member of the journal Endocrine and Metabolic Science (EMS) since 2024
  • Member of the International Society on Bone Marrow Adiposity (BMAS) Scientific Board since 2020
  • Member of the Biobanking working group of the BMAS since 2018
  • Expert member of the Regional Animal Experimentation Ethics Committee since 2010
  • Reviewing and Guest Editor in Frontiers in Endocrinology (2018-2019)

Awards and distinctions

  • Research award RIPEC C3 from ULCO/CNU, 2022-2025
  • Invited lecture to the congress of the French Association of study and research on obesity (AFERO), 2018, L’adiposité médullaire et l’Os, des liaisons dangereuses?
  • Invited lecture to the European Congress of Endocrinology (ECE), 2016, Bone Marrow Adipose Tissue and Bone, a bad romance?

 

Bibliography and CV:

ORCID Number: 0000-0001-7530-7486
 
on Research gate
 
Open Access on HAL
 

			

				
		
															
						

				
Contact

								
Email: Stephanie.Lucas@univ-littoral.fr