3D Cellular models
The MABLab laboratory uses 2D cellular models, and more recently 3D organoid cellular models, to study the interactions between osteoblasts and bone marrow adipocytes and understand the mechanisms underlying the pathology of osteoporosis.
Organoids are self-organizing 3D cell aggregates generated from several cell types that reproduce cellular heterogeneity and structure of tissue or organ. Bone-like organoids built from the assembly of bone marrow stromal cells and endothelial cells enable in vitro reproduction of the bone environment. Specific analytical tools and cellular imaging allow to monitor the generation and development of such cellular structures and explore their regulatory mechanisms.
Bone-like organoids can also be used for research on other bone disease, drug screening or bone regeneration.
